Lang - Currency



Manufacturers

Dapovar

Dapovar

The best offer ever for Dapovar in Dubai

More details


AED320

701953601145

Availability: Back-Order (ships in 10-14 business days)


Notify me when available

Loyalty programBy buying this product you can collect up to 320 loyalty points. Your cart will total 320 points that can be converted into a voucher of AED32.


Dapovar – How It Works

Dapovar™ success as a Duration Performance Enhancer ™can be attributed to its ability to act as a Selective Serotonin Reuptake Inhibitor (SSRI). In a nutshell, what Dapovar™ does is act on a region of your brain that controls and determines the rate at which you ejaculate. By manipulating this isolated receptor in your brain with our natural formula we are able to delay ejaculation significantly.

Let’s take a more detailed look at how and why Dapovar™ works.

First, let's look at these words that make up SSRI briefly. Selective is just a pharmacological term to mean that the drug acts only on a particular aspect of the brain as opposed to impacting on many different systems. Serotonin is a chemical in the brain that is used to send messages between cells/neurons - for this reason it's called a neurotransmitter. Reuptake is a process used by neurons in the brain to collect back chemicals that they use to send messages. And finally, Inhibitor is used to here to say that the drug blocks or inhibits this reuptake process. These concepts will be covered in more detail soon.

Serotonin: its home and function
Serotonin is a very important neurotransmitter chemical in the brain due to its chief role of regulating ejaculation response among other things. It isn't difficult to imagine that a common theme amongst those with premature ejaculation issues is some kind of abnormality in the serotonin system.

Neurons - the cells that make up the brain - can be defined by the type of chemical they use to communicate with. Neurons that use serotonin to communicate with other neurons can therefore be called serotonin neurons. The bulk of serotonin neurons in the human brain (and most animals) can be found in a cluster of cells called the raphe nuclei. This area is roughly near the base of your brain, in the middle of your head.

From their strategic position here, the serotonin neurons project out (kind of like tentacles) and release serotonin in many other parts of the brain to regulate timing of ejaculation. Neurons communicate with and influence other neurons by firing and releasing their neurotransmitter. This firing is pretty much what it sounds like: the neuron builds up an electrical charge, and when a threshold is reached, it 'fires', driving the release of the neurotransmitter chemicals from the tips of the neuron's 'tentacles'/projections.

An important part of the brain is what we call receptors. You can think of how receptors work in terms of a lock and a key: the receptor is a lock that is shaped to receive a particular chemical neurotransmitter (the key). When the correct neurotransmitter/key is associated with the receptor/lock the receptor is activated, causing a physical change in the neuron, which leads to some action.

Transporters and the effect of SSRIs

Another key part of the brain is transporters. These sit on the end of the neuron's projections and collect up the neurotransmitter that is released during communication. The brain has a built-in function to collect and recycle neurotransmitter chemicals that have done their job in activating receptors on other neurons. This process is also called reuptake or re-absorption (in the diagram).

Accordingly, the serotonin transporter acts to take serotonin molecules back up into the end of the serotonin neuron's projections. This is the function of the brain that is inhibited by Selective Serotonin Reuptake Inhibitors! SSRI drugs inhibit the reuptake of serotonin back into the cell, causing serotonin to pool outside of the cell. Here the serotonin continues to activate the receptors in the local area - continuing to have an impact on all the things serotonin is involved in regulating.

We now know at a basic level what SSRIs do in the brain: increase serotonin levels and activation. That should solve the premature ejaculation issues right? Turning low serotonin back into normal serotonin levels?
However, there's an interesting little fact that originally troubled researchers: serotonin levels are increased quickly within hours or days after starting to take 5HTP, however men do not last longer, and can even in some cases ejaculate even quicker, until around 2-3 weeks after starting with 5HTP based compounds. So what's happening during those 2-3 weeks with some men?

Serotonin 1A receptor
One of the receptors in the brain is called the serotonin 1A receptor. The 1A receptor is found on the serotonin neurons and its 'key' is serotonin. It has been discovered by clever scientists that activating this 1A receptor causes the serotonin neuron to quiet down - to decrease the rate at which it fires and the rate at which it makes new serotonin. It essentially acts as a way to turn down serotonin's influence in the brain, and as it's activated by serotonin itself, it acts like a feedback mechanism or thermostat of sorts. You could imagine it yelling out to the serotonin neuron "hey, we've got a lot of serotonin already out here, go easy on the production and drop the firing rate."

How, you may be wondering, does this relate to what SSRIs do? Well, we've seen how SSRIs cause an increase in serotonin and hence an increase in activation of serotonin receptors. The 1A receptor therefore gets its share of extra activation. Activation then, in an almost perverse way, reduces the firing of serotonin neurons and hence the release of serotonin.

Desensitization
At this point you need to know another concept of receptors: desensitization. When receptors are bathed in an unusually high amount of neurotransmitter chemicals, as is the case when SSRI drugs block the serotonin transporter, they react to their changing environment. In a word, they desensitize.

Desensitization is a complex topic, so we'll keep it simple. The end result is that more serotonin than before is required to activate the 1A receptors - they're less sensitive to the charm of the serotonin key. This means your orgasm will be delayed!!

Tying it all together
The theory is then that in the 2-3 week period mentioned earlier, the increased levels of serotonin caused by SSRIs are causing the desensitisation of the serotonin 1A receptors - a process that requires 2-3 weeks. During this time of desensitisation the SSRIs are raising levels of serotonin, which causes activation of the 1A receptor and the shutting down of the serotonin neurons. Over time, the 1A receptor becomes less sensitive to the effects of these raised serotonin levels (desensitisation), so the serotonin neurons are 'less shut down' and become more active. Therefore the serotonin firing rate and communication with other neurons is improved.

This improved serotonin transmission allows serotonin neurons to have more regulatory control in all the brain areas it has projections to, which leads to improvements in the associated functions, such as mood.

This is in a simple sense the current theory of how SSRIs can be used to end premature ejaculation

Cart  

(empty)

Specials

All specials

FEEDBACKS

I think Lion's mane is helping my son. He was diagnosed with autism when he was 4 years old. I am doing biomedical interventions since then (3 and a half years), and he is really improving. With lion's mane I saw big improvement in his imitation and he started to learn new words without teaching him those new words.


Reem Hamzah